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Introduction: Antibiotic resistance is a significant threat to the effective treatment of urinary tract infections (UTIs). The frequency of antibiotic-resistant UTIs is becoming increasingly concerning due to the possible consequences for patient health and healthcare expenses. Methodology: A retrospective research at DHQ Hospital Mirpur AJK examined 225 patients with febrile UTIs from Dec 2023 to Feb 2024. Urine samples were collected and antibiotic testing were performed in accordance with Clinical and Laboratory Standards Institute standards. Results: The study revealed alarming antibiotic resistance rates in urine isolates. Klebsiella spp. showed high resistance to Ceftriaxone (54%), Colistin (57%), and Cefuroxime (86%). Staphylococcus aureus exhibited significant resistance to Erythromycin (64%) and Doxycycline (81%). Escherichia coli displayed resistance to Ceftriaxone (23%) and Amoxicillin (25%). Notably, all species were susceptible to Vancomycin, with no observed resistance. Conclusion: This study demonstrates significant antibiotic resistance among bacterial species that cause urinary tract infections (UTIs), with Klebsiella pneumoniae showing the highest resistance rates. Effective antibiotic stewardship are urgently required to address this issue and enhance UTI care.
Khurshid et al. (Fri,) studied this question.