Formulation and evaluation of fast dissolving film of haloperidol

The present research work was designated towards formulation development of fast dispersible films of Haloperidol that possesses acceptable taste, mechanical strength and rapid disintegration to provide desired drug release property and pleasant mouth feel, for improving patient compliance, especially in pediatric and geriatric population. The aim of the study is to formulate Mouth dissolving film of Haloperidol an antipsychotic drug to improve the efficacy and patient compliance. In the present work, an attempt is made to develop Mouth dissolving film of Haloperidol with the use of hydroxymethyl cellulose (HPMC) as plolymer, xanthan Gum as binder, polyethylene glycol (PEG) as polymer, Citric acid as preservative, sacralose as sweetening agent and menthol as flavoring agent. Solvent casting technique was used to prepare the mouth dissolving film. The formulated fast dissolving film of Haloperidol was evaluated for different parameters: weight variations, thickness, folding endurance, percentage of drug content, surface pH, disintegration test, in vitro drug release and Stability study. Based on this physiochemical characterization in vitro drug release studies of Haloperidol showed 99% of drug at the end of 8 th minutes. The evaluation test for films of Haloperidol suggest that it is promising to be developed as fast dissolving films with above mentioned excipients which can enhance the release of drug and thereby the bioavailability may be improved and formulations were found to be stable.