Clinico-Bacteriological Study and Antibiotic Resistance Pattern of Urinary Pathogens in Pediatric Patients in a Tertiary Care Center at Kanpur

Background: UTI in children is an infection that occurs within the urinary tract system, which consists of the urethra, bladder and kidney. The infection is named after the location in the urinary tract. In the pediatric age group, incidence of morbidities of bacterial infections ranks second after that of upper RTI. Common uropathogens include Escherichia coli, Klebsiella, Pseudomonas aeruginosa Staphylococcus, saprophyticus, and Enterococcus. The aim of the study is to determine the Clinico-Bacteriological Study and Antibiotic Resistance Pattern of Urinary Pathogens in Pediatric Patients at a Tertiary Care Centre at Kanpur. Material and Methods: This study was conducted in children with suspected urinary tract infections from January 2017 December 2017 in Rama Medical College Hospital and Research Centre Kanpur. Urine samples were collected for urinalysis and culture. AST was performed as per the CLSI guidelines 2016. Result: Out of 100 children studied significant bacteriuria was detected in 47 cases. Male constituted (61.70%) and females were (38.30%). Escherichia coli, Klebsiella oxytoca Klebsiella pneumoniae, Pseudomonas aeruginosa, methicillin sensitive staphylococcus aureus and Enterococcus faecalis and yeast were the uropathogens. Common uropathogens isolated from this study showed high resistance to widely used antibiotics especially amoxycilin cefotaxime, ceftriaxone, ofloxacin, levofloxacin amikacin erythromycin, clindamycin, tetracycline, co-trimoxazole, nitrofurantoin. Conclusion: Males were more affected with UTI. Escherichia coli was the most commonly encountered uropathogen followed by Klebsiella species. Colistin, piperacillin tazobactum, gentamycin, imepenem, meropenem, norfloxacin vancomycin, tigecycline, tetracycline, co-trimoxazole linezolid, teicoplanin have lower antibiotic resistance rates and can be used in the treatment of UTI in children.