Correlation of Biochemical Markers and Inflammatory Cytokines in Autism Spectrum Disorder (ASD)

Abstract Introduction Autism Spectrum Disorder (ASD) is a disorder that severely affects neurodevelopment, and its underlying causes are not yet entirely understood. Research suggests that there may be a connection between the occurrence of ASD and changes in immune responses. This study aims to know if some biochemical and inflammatory cytokines are promising biomarkers for ASD and whether they are involved in the pathogenesis of ASD. Methods The serum levels of CRP, TNF-α, TGF-β, IL-1β, IL-10, 1L-8, and IL-6 were measured in all of the patients (n=22) and in the healthy (n=12) children using ELISA method. Results The serum concentrations of IL-10, IL-8, and IL-6 were significantly lower in the ASD patients compared to the control group (pConclusion The significantly decreased concentrations of IL-6, IL-8, and IL-10 in ASD patients, moreover the correlations among CRP, IL-8, and IL-10, may have a role in the pathogenesis of ASD and be considered as promising biomarkers for accurate diagnosis, prognostic prediction and effective treatment.