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We generated a myelin water atlas template derived from QPM. Imaging data were acquired using a multi-gradient-echo sequence for QPM. All the data in the 48 white matter regions measured in the volume-of-interest were plotted, and quadratic polynomial equations of each region were derived from the relationship between R1·R2* and the two-component model-MWF. As a result, the relationship between R1·R2* and MWF showed a strong significant correlation for all of the white matter regions (R2 ≥ 0.963, P < 0.0001). Our myelin water atlas template derived from QPM can be used as a reference to demonstrate areas of demyelinating disease.
Kanazawa et al. (Wed,) studied this question.