Comparing the Repeatability of Cerebrovascular Reserve Measured by PET and ASL using Simultaneous PET/MRI

Cerebrovascular reserve (CVR) is an important biomarker to assess vascular hemodynamics and link to the risk for acute strokes. Whilst several imaging modalities have been applied to measure CVR, their reproducibility remains to be elucidated. Here we compare the reproducibility of CVR measurements in 22 normal subjects between single and multi-delay ASL using 15O-water PET as the reference. Results implied that multi-delay ASL achieved a higher reproducibility and should be the preferred non-invasive modality for clinical applications.