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Currently 50 million people suffer from Alzheimer’s disease (AD), the most common form of dementia, yet treatment options are limited. A growing focus on the contribution of cerebrovascular (CV) health presents new possible targets for treatment. We investigated novel CV imaging markers using 4D flow MRI in a total of 43 participants with mild cognitive impairment, early AD and controls. Both the MCI and AD group had significantly reduced mean blood flow in the larger vessels of the Circle of Willis. A significantly increased pulsatility index (indicative of poorer vessel compliance) was found in the AD group compared to controls.
Elsayed et al. (Wed,) studied this question.