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The white matter (WM) network integrity is assumed to associate with Alzheimer's disease (AD)-related gray matter (GM) atrophy. To investigate this hypothesis, we estimated WM-specific brain age to quantify WM integrity and calculated twelve AD-related GM signatures in a longitudinal cognitively normal cohort. We identified that the change rate of WM brain age was significantly correlated with the left hippocampal and amygdala volumetric changes; that is, the accelerated aging in WM was associated with the more atrophic GM volumes. This result suggested that changes of structural network characterized by brain age metrics can reflect the alteration of AD-related GM signatures.
Chen et al. (Wed,) studied this question.