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Dixon-derived fat fraction (FF) has proven to play a pivotal role in whole-body MRI examinations for assessment of bone marrow disease in advanced prostate cancer. However, Dixon sequences are known to be subject to multiple sources of bias compared to the proton-density fat fraction (PDFF) gold standard. In this study, FF within the pelvis was measured for healthy tissues, active lesions and treated lesions with six different Dixon sequences. All sequences demonstrated good repeatability in scan-rescan studies of healthy volunteers. Statistically significant differences were observed between T1w-FF and PDFF for both active and treated lesions which requires further investigation.
Azma et al. (Wed,) studied this question.