Passive Device Tracking for interventional MRI with Ferric Ion Chelated Natural Melanin Nanoparticles

Natural melanin nanoparticles (MNPs) labeled with paramagnetic ions provide a potential MRI contrast enhancing material alternative to current MRI contrast agents due to their biocompatibility, biodegradability, metal, and biomolecule chelation properties. In this study, we investigated T1 shortening effect of Fe3+ chelated MNPs solution compared to gadolinium-based contrast agents under 3T MRI. Then, we examined traceability of MNP-Fe3+ ions deposited interventional nitinol guidewire in MR scans. Results clearly showed that the coating of Fe3+ chelated MNPs over the surface of MRI compatible instruments will increase traceability of interventional devices in MRI.