Single-shot GABA Editing at 7 Tesla

Two-step editing techniques have been widely used to detect the GABA H4 signal at 3.01 ppm with the dominant creatine methyl proton signal cancelled by subtraction. However, subtraction is inherently sensitive to patient movements and system instability. In this work, a single-shot spectral editing technique is developed to detect the GABA H2 resonances at 2.28 ppm in the human brain at 7 Tesla. Although GABA H2 is partially overlapped by glutamate H4, we demonstrate that GABA-glutamate correlation originating from spectral overlap can be reduced to practically zero, therefore suppressing the overlapping effect of glutamate H4 on GABA H2 without subtraction.