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Conventional saturation transfer MRI approaches, such as magnetization transfer contrast (MTC) and chemical exchange saturation transfer (CEST) MRI, acquire qualitative contrast weighted images, without specific information on the quantitative parameters affecting contrast, namely proton exchange rate and concentration. In addition, the contrast weighted images are highly dependent on scan parameters and data acquisition strategies. Here, we developed a fast, quantitative saturation transfer (ST) imaging technique based on MR fingerprinting principles to simultaneously estimate free bulk water, semisolid macromolecule, and amide proton-related parameters. The approach was evaluated with Bloch simulation and synthetic MRI analysis using in vivo human brains.
Singh et al. (Wed,) studied this question.