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fMRI with ultrahigh resolution has typically been acquired at 7T in order to overcome the inherently low SNR at 3T. However, 7T scanners are inaccessible to the majority of investigators. In this study, we developed new acquisition and reconstruction approaches and employed the denoising method NORDIC to improve the resolution of 3T fMRI to 1 mm isotropic with whole-brain coverage and volumetric scan time of 2 seconds. Our results showed improved tSNR and low spatial blurring. The detection capability of resting-state networks was comparable to that of 7T. BOLD activations in cortical and subcortical regions were observed in task-based fMRI.
Chang et al. (Wed,) studied this question.