Accelerated Sampling Strategy for High-resolution 3D T1rho Dispersion MRI with 4D Dynamic Radial Acquisitions

T1ρ dispersion imaging based on repeated T1ρ measurements at multiple spin-lock frequencies allows characterization of different dynamic processes of tissues. The clinical potential of these techniques is, however, limited by the total scan time needed to obtain reliable and consistent quantitative measurements. In this abstract, we propose the application of a 4D dynamic sequence with radial acquisitions in combination with an accelerated data-point sampling strategy to achieve efficient coverage of the high-dimensional data space in T1rho dispersion MRI, which leads to high-resolution 3D T1rho dispersion imaging acquired within clinically acceptable scan duration of ~5 minutes.