Repeatability and reproducibility of a multi-vendor spin and gradient echo (SAGE) pulse sequence for dynamic susceptibility contrast MRI

Single-echo pulse sequences are commonly employed for DSC-MRI. The multi-echo spin and gradient echo (SAGE) sequence can be useful in multi-contrast and multi-scale imaging of morphologic and functional features of brain tumor vasculature. The goal of this study is to establish harmonized SAGE sequence and analysis protocol across primary MRI vendors to facilitate multi-site clinical trials. In this work, we present initial results of SAGE sequence multi-site reproducibility and repeatability in phantom, healthy volunteers and high-grade glioma patients.