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Multiple Sclerosis (MS) is an autoimmune disorder characterized by focal inflammatory demyelination. Chronic MS lesions can contain chronically activated, iron-laden microglia and macrophages. By comparing rim status on quantitative susceptibility mapping (QSM) and phase imaging with histopathology that identifies iron, we demonstrate that QSM is a more reliable indicator of iron status than phase. QSM is a valuable clinical tool to identify iron positive smoldering lesions not visible using conventional MRI techniques.
Gillen et al. (Wed,) studied this question.
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