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This study examined baseline and age-related differences in white matter perfusion and microstructural integrity across ten tracts of interest using 535 adult subjects of the Human Connectome Project in Aging. Whole-brain and tractwise relationships were identified between age, cerebral blood flow, mean diffusivity, and fractional anisotropy. Additionally, regional differences in age-related perfusion and microstructural trajectories were identified, representing one of the first direct examinations of regional variation in white matter perfusion in aging.
Robinson et al. (Wed,) studied this question.