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Mutations in the genes encoding for isocitrate dehydrogenase (IDH), and 1p/19q codeletion are genetic alterations that can be often found in low-grade gliomas and are associated with better prognosis and response to treatment. Nevertheless, the biological effects of the 1p/19q codeletion are still not well known. In this study, we compared the neurochemical profile of IDH-mutated, 1p/19q codeleted gliomas and their non-codeleted counterparts using in vivo magnetic resonance spectroscopy. We showed that the only metabolite that differed significantly between the two groups was cystathionine, pointing to this metabolite as the most useful biomarker for the identification of 1p/19q codeleted gliomas.
Branzoli et al. (Wed,) studied this question.