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Recent studies have consistently reported that BOLD effects in WM reflect neural activities, and thus represent a new window into brain function. Here we evaluate the potential value of BOLD measurements in WM as an indicator of functional changes during normal aging. We observed a widespread reduction of metrics of WM BOLD effects, suggesting changes occur in information exchange in WM with aging. Our findings converge to support the notion that WM BOLD signals in specific regions and their interactions with others have the potential to serve as imaging markers of aging.
Li et al. (Wed,) studied this question.