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CEST imaging requires a high SNR to detect low metabolite concentrations, especially at clinical used magnetic field strength (3 Tesla). In recent years, various approaches have been used to denoise CEST data. Our study investigated the performance of different denoising algorithms using 1000 synthetic CEST MR data. Our results showed that PCA produced the best denoising results for CEST MR imaging in a simulation study.
Radke et al. (Wed,) studied this question.