Static and Dynamic Alteration of Intrinsic Brain Activity might improve MRI-negative Temporal Lobe Epilepsy Diagnosis and Lateralization

We comprehensively explored the potential intrinsic brain activity (IBA) abnormalities affected by MRI-negative temporal lobe epilepsy (TLE) based on six temporal dynamic indicators (dALFF, dfALFF, dReHo, dDC, dGSCorr, dVMHC) and their corresponding static indicators, the results revealed that the abnormally activated brain regions overlap markedly, including ①decreased fALFF, Reho, DC, VMHC, dfALFF, dReHo in the temporal neocortex with ipsilateral superiority. ②decreased dGSCorr and dVMHC in the occipital lobe. Moreover, many IBA indicators significantly correlated with the epilepsy duration or cognitive scale scores. The dDC, fALFF and DC showed significant discrimination ability. The ReHo and fALFF demonstrated lateralization significance.