Key points are not available for this paper at this time.
Conventional quantitative susceptibility mapping (QSM) reconstruction methods only provide voxel-averaged susceptibility value. We proposed a comprehensive complex signal model that describes the relationship between the 3D GRE signal and the contributions of opposing susceptibility to the frequency shift and R₂^* relaxation. We used an iterative data fitting scheme to alternatively determine the sub-voxel susceptibilities and the voxel-wise proportionality coefficient between R₂' and absolute susceptibility. Our experiments on in-vivo human brain data compared with histological staining images demonstrate that the proposed method provides more accurate results for quantifying brain iron and myelin than previous QSM separation methods.
Li et al. (Wed,) studied this question.