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Transient hypoxia-induced BOLD-DSC perfusion imaging approach can noninvasively map cerebral blood flow (CBF) and cerebral blood volume (CBV) in animals with injectable anesthetics. Since animal models are frequently investigated in translational research under volatile anesthetics, we developed a simple gas delivery system for inducing transient hypoxia, and performed perfusion studies of mouse under isoflurane and dexmedetomidine. Highly sensitive and reproducible perfusion metrics were found, and regional impact of anesthesia to basal perfusion metrics was assessed.
LE et al. (Wed,) studied this question.