3D Isotropic and high resolution whole brain DWI with single slab and single shot EPI utilizing motion compensated diffusion gradients

3D Diffusion imaging (3D DWI) has showed great potential in probing tissue microstructure and brain structural connectivity. However, motion-induced phase errors introduced by diffusion gradients will cause severe artifacts in 3D DWI. Multi-slab can be used to overcome this limitation, but it will introduce slab boundary artifacts. We propose a method which utilizes motion-compensated diffusion gradients for 3D DWI to mitigate the phase error between shots. Results from in vivo data demonstrate the proposed method can improve image quality and realize an isotropic high resolution and whole brain 3D DWI in a single slab.