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Recent MRS community consensus recommended sLASER over PRESS for reduced chemical-shift displacement. There is very little evidence supporting this consensus in terms of ability to reveal in vivo biochemistry. sLASER- and PRESS-localized spectra were collected in gray- and white-matter regions in 102 adult subjects (aged 20-69). sLASER showed slightly higher SNR than PRESS (by 4% on average), but improved SNR and localization did not convert into reduced variance or improved detection of metabolite-age correlations. Between-subject CVs of 13 modeled metabolites were remarkably consistent, and the pattern of metabolite-age correlations was also similar.
Hui et al. (Wed,) studied this question.
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