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A multi-parametric MR Spectroscopic Imaging (MRSI) experiment (Multi-Echo Single-Shot MRSI, MESS-MRSI) deploys partially sampled multi-echo trains from single readouts combined with simultaneous multi-parametric model fitting to produce metabolite-specific T2 and concentration maps in 7min. It was tested in-vivo on a cohort of 5 subjects. Cramer-Rao Lower-Bounds (CRLBs) are used as measure of performance. The novel scheme was compared with the (i) traditional Multi-Echo Multi-Shot (MEMS) method and (ii) a truncated version of MEMS, which mimics the MESS acquisition (MESS-mocked). Results extended former findings for single voxel measurements with improvements in CRLB ranging from 17-45% for concentrations and 10-23% for T2s.
Rizzo et al. (Wed,) studied this question.
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