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Quantitative susceptibility mapping (QSM) calculates the tissue magnetic susceptibility from gradient-echo phase images. Tissue magnetic susceptibility is of high clinical interest because it reflects tissue iron, myelin, and calcium. However, the clinical significance of these findings remains unclear. In particular, it is unknown if algorithms differ in their ability to detect group differences and longitudinal changes in susceptibility. The present work compared a large number of published algorithms with respect to their ability to detect aging-related changes over time.
Salman et al. (Wed,) studied this question.