Key points are not available for this paper at this time.
Abstract Background and Objective Correlations between the image analysis of CT scan, lung function and quality of life in patients with idiopathic pulmonary fibrosis (IPF) remain unclear. This study aimed to investigate the impacts of pulmonary blood‐vessel distribution and the extent of fibrosis on the lung function and quality of life of patients with IPF. Methods Patients were enrolled in an IPF registry and had completed pulmonary function tests, chest HRCT, St. George Respiratory Questionnaire (SGRQ) and echocardiography. Pulmonary blood‐vessel distribution, specific image‐derived airway volume (siVaw) and fibrosis extent (siVfib) were quantitatively calculated by functional respiratory imaging on HRCT. Results The study subjects were categorized into DLco <40% pred. ( n = 40) and DLco ≥40% pred. ( n = 19) groups. Patients with DLco <40% pred. had significantly higher scores of SGRQ, composite physiologic index (CPI), exercise oxygen desaturation (∆SpO 2 ), siVaw, lower FVC% pred. and 6‐minute walking distance% pred. The proportion of small blood vessels in the upper lobes (BV5PR‐UL) was significantly correlated with CPI, DLco % Pred., FVC% pred., SGRQ and ∆SpO 2 . Only BV5PR‐UL had a significant impact on all indices but not BV5PR in the lower lobes (BV5PR‐LL). siVfib was significantly negatively correlated with BV5PR‐UL, DLco% pred. and FVC% pred., as well as positively correlated with CPI, ∆SpO 2 and siVaw. Conclusion BV5PR‐UL and siVfib had significant correlations with lung function and may become important indicators to assess the severity of IPF and the impact on quality of life.
Hu et al. (Thu,) studied this question.