Invasive Nontypeable Haemophilus influenzae Disease Outbreak at an Elementary School — Michigan, May 2023

In May 2023, the Detroit Health Department was notified of four cases of invasive nontypeable Haemophilus influenzae (Hi) disease among students attending the same elementary school and grade, all with illness onsets within 7 days.Three patients were hospitalized, and one died.Most U.S. cases of invasive Hi disease are caused by nontypeable strains.No vaccines against nontypeable or non-type b Hi strains are currently available.Chemoprophylaxis is not typically recommended in response to nontypeable Hi cases; however, because of the high attack rate (four cases among 46 students; 8.7%), rifampin prophylaxis was recommended for household contacts of patients with confirmed cases and for all students and staff members in the school wing where confirmed cases occurred.Only 10.8% of students for whom chemoprophylaxis was recommended took it, highlighting gaps in understanding among caregivers and health care providers about persons for whom chemoprophylaxis was recommended.Public health authorities subsequently enhanced communication and education to the school community, improved coordination with health care partners, and established mass prophylaxis clinics at the school.This outbreak highlights the potential for nontypeable Hi to cause serious illness and outbreaks and the need for chemoprophylaxis guidance for nontypeable Hi disease.Achieving high chemoprophylaxis coverage requires education, communication, and coordination with community and health care partners.