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Abstract Pyrrole is a heterocyclic structure with diverse pharmacophores, enabling the creation of an extensive lead molecule library. Its broad range of pharmacological profiles has concerned significant global research interests. This review highlights recent advancements in pyrrole scaffolds, focusing on their structure active relationship and bioactivities. Pyrrole derivatives recognized for their biological activities, are promising scaffolds for developing antimicrobial, antimalarial, antiviral, antituberculosis, and enzyme‐inhibiting properties. Their unique anti‐inflammatory and antioxidant features have prompted the development of novel cardioprotective and neuroprotective compounds. The review aims to elucidate the SAR of pyrrole mimics, aiding future therapeutic developments.
Sahu et al. (Fri,) studied this question.