Therapeutic Implications of Neurological Drugs For Prions Disease

Prion diseases is a neurodegenerative disorder that effects the brain and nervous system. This disease alters the normal functioning of nervous system and have same molecular mechanism and proteins involved both in humans and animals. Prion disease is caused by the deposition of abnormally folded proteins in the brain, that causes changes in memory, behavior, and movement. Prion diseases causes a progressive decline in the brain function due to misfolding of proteins called prion proteins (PrP). Misfolded PrP begins to accumulate and form clumps within the brain, damaging and killing nerve cells. Current research was done to screen and study the neurological drugs against prion disease. To predict potential drug that can be used for drug development and discovery. In this research two prion proteins i.e., PrPLP /Prion Protein 2(PDB ID: 1I4M) and ERI1 Exoribonuclease 3protein (PDB ID: 2XRI) were selected as drug target. These proteins were docked against 20 ligands screened from PubChem database. These 20 ligands were selected based on reference research papers, extensive literature search and these ligands have function in neurological diseases and act as drug. Twenty selected ligands were docked against target protein using CB dock server. Docking result shows that Prion protein 2 shows best interaction with Celastrol with a Vina Score of -8.2 and in ERI1 Exoribonuclease 3 shows best interaction with Celastrol and Amisulpride with a Vina score of -9.7 and -8.8 respectively. This study gives insight into the potential ligand for prion disease and can be used for drug designing process.