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HLA‐lacking clones in aplastic anaemia: Adaptive or maladaptive? | Synapse

August 26, 2024Open Access

HLA‐lacking clones in aplastic anaemia: Adaptive or maladaptive?

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Abstract

HLA loss represents the result of immune forces shaping bone marrow clonal dynamics in immune aplastic anaemia. Human leukocyte antigen (HLA)-deficient clones may rescue haematopoiesis by evading immune attacks, potentially guiding treatment strategies. Commentary on: Zaimoku et al. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024; 205:1995-1999.

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Cite This Study

Gurnari et al. (Mon,) studied this question.

synapsesocial.com/papers/68e5af05b6db643587548d4c https://doi.org/https://doi.org/10.1111/bjh.19731

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