Figure 6 from Clinically Relevant Humanized Mouse Models of Metastatic Prostate Cancer Facilitate Therapeutic Evaluation

Immune-dampened profile of T cells in huNOG-EXL tumors. A, Gating strategy for determining the activation state of T cells and regulatory-like T cells. B, Representative data showing the activation state of the CD3+ cells harvested from tumors under different treatment categories through the presence of the surface markers: CD25, CD44, CD69, and PD-1 and regulatory-like cells (CD3+CD25+PD-1+). C, Quantitation showing the expression of CD25 (D), CD44 (E), CD69 (F), PD-1 (G) regulatory-like T cells.