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Ocimum basilicum is a phenols-rich plant; used in traditional medicine to treat many diseases such as digestive and respiratory diseases.Very few studies focused on the anticoagulant effect of basil extracts. This study aimed to investigate the anticoagulant effect of aqueous Basil extract, by testing its effect on prothrombin time PT in vitro using plasma taken from healthy people and patients treated with Warfarin. Five aqueous extracts were prepared from a mixture of flowering tops and leaves, the first extract was prepared using 2 grams of the harvested plant, and the rest were prepared using 2, 5, 10, 15 grams from crushed mixture. The content of phenolic compounds in the extracts reached, respectively, (0.693, 1.35, 6.10, 9.50, 13.93) gGAE/l. All extracts showed a significant prolongation inPT compared with the blank in both healthy and warfarin- treated subjects, and the effect was concentration-dependent. The EC50 value in healthy people was (6.026) gGAE/lhigher than the EC50value in patients receiving warfarin which was (1.26) gGAE/l,. These results indicate a possible anticoagulant effect of aqueous basil extracts, and suggest a possible synergistic effect with warfarin.
Masoudi et al. (Wed,) studied this question.