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High-dose methotrexate (HDMTX) use can be limited by the development of acute kidney injury (AKI). Early AKI detection is paramount to prevent further renal injury and irreversible toxicities. This study sought to determine whether early elimination patterns of MTX would be useful as a biomarker of AKI in HDMTX treatment.
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Nicolás Tentoni
Miriam Hwang
Gabriela Villanueva
Cancer Medicine
Istituti di Ricovero e Cura a Carattere Scientifico
Cincinnati Children's Hospital Medical Center
University of Cincinnati Medical Center
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Tentoni et al. (Sun,) studied this question.
www.synapsesocial.com/papers/68e59c66b6db6435875371cc — DOI: https://doi.org/10.1002/cam4.70176