Nicardipine pharmacokinetic parameters were increased by 5-fold in hepatic cirrhosis patients compared to controls, and its administration notably reduced blood pressure in renal-impaired patients.
Systematic Review
What are the clinical pharmacokinetic and pharmacodynamic parameters of nicardipine in humans?
This systematic review provides comprehensive data on the clinical pharmacokinetics and pharmacodynamics of nicardipine, highlighting a 5-fold increase in exposure in hepatic cirrhosis patients and significant blood pressure reduction in renal-impaired hypertensive patients.
INTRODUCTION: Nicardipine is a type of calcium channel blocker that is commonly used in the treatment of angina pectoris, hypertension, and related cardiovascular disorders. This systematic review assesses the reported pharmacokinetic (PK) and associated pharmacodynamic (PD) parameters of nicardipine in humans. AREAS COVERED: of nicardipine was increased by 5-fold in hepatic cirrhosis patients compared to the control subjects. Moreover, related PD data in renal-impaired hypertensive patients revealed that a notable reduction in blood pressure was associated with nicardipine administration. EXPERT OPINION: This review covers comprehensive data on clinical PK, drug-drug interaction studies, effects of dosage form on ADME, and associated PD parameters of nicardipine using all relevant published studies. The present study will also aid in the development and evaluation of PK models for suggesting model-informed dosing regimens. PROSPERO NUMBER: CRD42024533051.
Ayub et al. (Tue,) conducted a systematic review in angina pectoris, hypertension, and related cardiovascular disorders. Nicardipine was evaluated on pharmacokinetic (PK) and associated pharmacodynamic (PD) parameters. Nicardipine pharmacokinetic parameters were increased by 5-fold in hepatic cirrhosis patients compared to controls, and its administration notably reduced blood pressure in renal-impaired patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: