Ag‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition of N‐2,2,2‐Trifluoroethylisatin Ketimines with Conjugated Exocyclic Double Bond: Access to Pyrrolidines with Four Consecutive Stereocenters Including Two Adjacent Spiro‐Quaternary Centers

Ag‐catalyzed enantioselective 1,3‐dipolar cycloaddition of N‐2,2,2‐trifluoroethylisatin ketimines with conjugated exocyclic double bond including α‐alkylidene succinimides and aurone derivatives was developed for the first time. Using a catalyst system consisting of a ferrocenyl P,N‐ligand and AgNO2, the reaction provides a facile method for the construction of chiral pyrrolidines bearing four consecutive stereocenters and two adjacent spiro‐quaternary chiral centers, as well as offers a direct route to structurally diverse enantioenriched CF3‐containing 3,2′‐pyrrolidinyl spirooxindole derivatives.