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Background & Objective: Pre-eclampsia is a hypertensive disorder linked with immune dysregulation and systemic inflammation in pregnancy. An elevated neutrophil count alongside a relatively stable lymphocyte count leads to an increased Neutrophil-to-Lymphocytic Ratio (NLR), serving as a parameter of widespread systemic inflammation. Platelet to lymphocyte ratio (PLR) is a also used as a hematological marker that reflects the balance between platelets and lymphocytes. A higher NLR and PLR may reflect increased endothelial activation and damage, contributing to the pathogenesis of preeclampsia. The objective of the present study was to compare the Neutrophil to lymphocytic ratio (NLR as well as platelet-to-lymphocytic ratio (PLR) between women affected by preeclampsia (PE) and those with uncomplicated pregnancies. Methods: It was a cross-sectional comparative study. Fifty-five registered preeclamptic patients were enrolled as cases along with fifty-five healthy pregnant women. Total leukocyte counts, including neutrophils and lymphocytes as well as platelet count, were calculated using an automated hematology analyzer, and the Neutrophil-to-Lymphocyte Ratio (NLR) as well as Platelet to Lymphocyte ratio were subsequently calculated. Results: Higher value of TLC and neutrophils were recorded in pre-eclampsia. The normotensive women had higher platelet as well as lymphocyte count. NLR was significantly high in the preeclampsia contrary to PLR ratio that showed a higher value in normotensive pregnancies. Conclusions: In conclusion, our study highlights significant alterations in the immune-inflammatory profile of patients with preeclampsia compared to controls. The observed high neutrophil-to-lymphocyte ratio (NLR) and low platelet-to-lymphocyte ratio (PLR) suggest a distinct systemic inflammatory response associated with preeclampsia.
Rana et al. (Sun,) studied this question.