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Abstract Parkinson's disease (PD) is known to impact both sexes, yet women exhibit unique clinical profiles and require tailored disease management strategies. This study sought to delineate the differences in sex and thyroid hormone levels, along with menstrual factors, in postmenopausal women with PD with motor complications and to evaluate their correlation with motoric issues. A cohort of 95 postmenopausal women with PD provided data encompassing menarche and menopause timing, menstrual cycle characteristics, and thyroid and gynecological histories. Hormonal and thyroid function assessments were conducted, correlating with PD patients’ clinical features and disease severity. Key findings include lower serum prolactin in women with PD and motor complications, a negative correlation between estradiol levels and HAMA scores, and no significant differences in menstrual characteristics between those with and without motor complications. Menarche age negatively correlated with cognitive scores, while the menstrual cycle and its duration showed associations with motor symptom severity. Women with motor complications demonstrated specific correlations between menopause timing, menstrual cycle, and psychological scores and presented with lower T3 and higher thyroid-stimulating hormone levels. T3 and FT3 levels were negatively linked to motor symptom severity and H-Y staging in this group. Motor complications in female PD patients are potentially linked to prolactin and T3 levels, underscoring the need for vigilant thyroid function monitoring. Advanced age at PD onset appears protective against motor complications, contrasting with the risks of extended disease duration and elevated NMSS scores.
Wan et al. (Tue,) studied this question.