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Gall Bladder can be affected by various pathologies of which gall stones and inflammatory conditions are common. Neoplasms are rare but can be fatal if diagnosed late, thus the histopathological studies of all the cholecystectomy specimen is essential. The aim of this study was to determine the histopathological spectrum of gallbladder lesions in cholecystectomy specimens and their association with age & sex of the patients. This study was done in the Department of Pathology, IIMSR in UP from May 2022 to February 2024. A total of 115 specimens were taken and their clinical details and histological findings were analysed. Out of 115 cases, gallstones and related diseases showed female preponderance 84 (73.04%), male patients were 31(26.95%). Maximum incidence was seen in 2nd & 3rd decade of life (64cases). Histopathological examination revealed Chronic cholecystitis (CC) with cholelithiasis was the most prevalent lesion (46 patients) which was followed by CC(25 cases),CC with cholestrolosis(11 cases),CC with cholestrolosis and cholelithiasis (8 cases),CC with pyloric metaplasia (5 cases),CC with reactive atypia (4 cases),CC with cholelithiasis and dysplasia (4 cases),Chronic fibrosing CC with focal reactive atypia(3cases),Acute on chronic cholecystitis with mild focal dysplasia(2 cases),Xanthogranulomatous CC(2 cases),CC with papillary hyperplasia(2 cases),CC with adenomatous hyperplasia and focal dysplasia(1 case),GB adenocarcinoma(1case),Intracystic papillary neoplasm with an associated invasive carcinoma(1 case).
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