The Role of Gut Microbiota in Psoriasis: Current Knowledge and Emerging Therapeutic Interventions

The introduction of the gut-skin axis as a new concept casts light on the complex relationship between dermatological maladies and the human intestinal microbiome. A wealth of evidence now substantiates the crucial involvement of the gut microbiota in the development of psoriasis, emphasizing the need for further exploration in this field. The development of psoriasis involves a combination of factors, making its pathogenesis multifactorial. In addition, psoriasis has been connected to several comorbid conditions. The intricate connection between gut health and skin homeostasis is established through the alteration of immune functions, highlighting the reciprocal nature of this association. This review delves into how an imbalanced gut microbiome can have detrimental effects on psoriasis. Furthermore, this review seeks to discuss potential and emerging therapeutic interventions, encompassing dietary approaches, probiotic supplementation, orally administered engineered bacteria, and phage therapy.