Racial and Geographic Differences in Endometrial Cancer Death

Introduction In the United States, endometrial cancer incidence rose by 4.5% annually from 1999-2015, reaching 18 per 100,000 women, with a disproportionate impact on Black women. Despite advancements in endometrial cancer research, racial disparities in mortality rates persist. Our retrospective cohort study aimed to investigate the mortality trends and disparities among patients with endometrial cancer in the United States. Methods Patients with endometrial cancer mortality from 1999 to 2020 were analyzed from the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER). Age-adjusted mortality rates (AAMRs) per 100,000 individuals were compared across different races and geographical regions. Results From 1999 to 2020, endometrial cancer accounted for 90,145 deaths in the United States. Overall, the AAMRs of endometrial cancer increased significantly from 2.50 (95% CI, 2.41-2.58) in 1999 to 3.94 (95% CI, 3.85-4.04) per 100,000 individuals in 2020, with an AAPC of +2.23 (95% CI, 1.39-3.07). The highest AAMR was observed among African Americans (2.69 95% CI, 2.65-2.74), followed by Whites (1.44 95% CI, 1.43-1.45), Hispanics (1.16 95% CI, 1.13-1.20), Asians (1.00 95% CI, 0.96-1.04) and American Indians (0.99 95% CI, 0.88-1.10). The highest AAMR from endometrial cancer was recorded in the Northeast region (1.73 95% CI, 1.71-1.76). Conclusion There was an increasing trend of mortality rates from endometrial cancer in the last two decades, which disproportionately affected African Americans. Targeted interventions are warranted to address the mortality disparities among patients with endometrial cancer.