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Cancer Stem Cells (CSCs), as a unique subset of tumor cells, play a crucial role in tumor initiation, progression, and recurrence due to their self-renewal and differentiation capabilities. CSCs exhibit significant immune evasion abilities, allowing them to escape host immune surveillance, leading to the failure of conventional treatments. This paper reviews the definition, characteristics, and immune evasion mechanisms of CSCs, including immune checkpoint pathways, immunosuppressive microenvironment, and changes in surface antigen expression. Additionally, it explores various immunotherapies targeting CSCs, such as immune checkpoint inhibitors, CAR-T cell therapy, tumor vaccines, and other emerging therapies, discussing their research progress and clinical application prospects. By comprehensively understanding the immune evasion mechanisms of CSCs and related immunotherapies, we aim to provide new insights and strategies for future cancer treatments.
Ziyang Zeng (2024) studied this question.