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Background: Benzimidazole derivatives are pivotal in medicinal chemistry due to their diverse therapeutic applications. Traditional synthesis methods often require catalysts and long reaction times, which can be inefficient and environmentally unfriendly. Hence, there is a growing need for more efficient and eco-friendly synthetic methodologies. Methods: A newly devised and efficacious synthetic methodology has been established for the synthesis of benzimidazole derivatives, employing microwave assistance without the requirement for a catalyst. This method facilitated the synthesis of fifteen derivatives with notable efficiency, characterized by significantly reduced reaction times ranging from 5 to 10 minutes and impressive yields ranging from 94% to 98%. Results: The identity and purity of the synthesized benzimidazole derivatives were meticulously verified through a comprehensive analysis, encompassing a comparison of their physicochemical properties and spectral characteristics with authenticated reference data. Conclusion: This method represents a significant advancement in the synthesis of benzimidazole derivatives, offering a rapid and high-yielding alternative to traditional synthetic routes.
Shah et al. (Wed,) studied this question.