Supplementary Fig. S16 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy

Supplementary Fig. 16. NOTCH3 inhibition blocks meningioma xenograft growth without causing toxicity. A, A NOTCH1 negative regulatory region neutralizing antibody (αNRR1), but not αNRR3, causes diarrhea and rash resulting in weight loss in mice harboring meningioma xenografts. Antibodies were delivered using biweekly IP injection. Student’s t tests. B, The -secretase inhibitor LY-411575 (GSI) delivered using daily IP injection causes diarrhea and rash resulting in weight loss in mice harboring meningioma xenografts. Student’s t tests. C, LY-411575 attenuates the growth of CH-175MN (left) or IOMM-Lee (right) meningioma xenografts in mice. Student’s t tests. Lines represent means and error bars represent standard error of means.