Both low- and high-volume HIIT significantly increased flow-mediated dilation (↑58.8% and ↑94.1%, p<0.001) and decreased carotid intima-media thickness and oxidized LDL in post-AMI patients.
RCT (n=80)
Does high-intensity interval training (low or high volume) improve vascular-endothelial function and reduce oxidative stress in patients after acute myocardial infarction?
Both low- and high-volume high-intensity interval training improve endothelial function and reduce oxidative stress and carotid intima-media thickness in post-AMI patients.
p-value: p=<0.001
Background: Determinants of coronary artery disease, such as endothelial dysfunction and oxidative stress, could be attenuated by high-intensity aerobic interval exercise training (HIIT). However, the volume of this type of training is not well established. Objective: To assess the impact of two volumes of HIIT, low (LV-HIIT, 10 min at high intensity), on vascular-endothelial function in individuals after an acute myocardial infarction (AMI). Materials and methods: Clinical trial in 80 AMI patients (58.4 ± 8.3 years, 82.5% men) with three study groups: LV-HIIT ( n = 28) and HV-HIIT ( n = 28) with two sessions per week for 16 weeks and control group (CG, n = 24) with unsupervised physical activity recommendations. Endothelial function (brachial flow-mediated dilation, FMD), atherosclerosis (carotid intima-media thickness ultrasound, cIMT), and levels of oxidized low-density lipoprotein (ox-LDL) as a marker of oxidative stress were determined before and after the intervention period. Results: After the intervention, in the exercise groups, there was an increase in FMD (LV-HIIT, ↑58.8%; HV-HIIT, ↑94.1%; p < 0.001) concurrently with a decrease in cIMT (LV-HIIT, ↓3.0%; HV-HIIT, ↓3.2%; p = 0.019) and LDLox (LV-HIIT, ↓5.2%; HV-HIIT, ↓8.9%; p < 0.001), with no significant changes in the CG. Furthermore, a significant inverse correlation was observed between ox-LDL and endothelial function related to the volume of HIIT training performed (LV-HIIT: r = −0.376, p = 0.031; HV-HIIT: r = −0.490, p < 0.004), with no significance in the CG ( r = 0.021, p = 0.924). Conclusion: In post-AMI patients, HIIT may lead to a volume-dependent enhancement in endothelial function, attributed to a decrease in oxidative stress, with added beneficial effects in reducing vascular wall thickness. An LV-HIIT program, with less than 10 min at high intensity per session, has proven enough efficiency to initiate favorable vascular-endothelial adaptations, potentially reducing cardiovascular risk among patients with coronary artery disease. Trial registration: INTERFARCT, ClinicalTrials.gov: NCT02876952.
Aispuru-Lanche et al. (Mon,) conducted a rct in acute myocardial infarction (AMI) (n=80). High-intensity aerobic interval exercise training (HIIT) vs. Unsupervised physical activity recommendations was evaluated on Vascular-endothelial function (brachial flow-mediated dilation, FMD) (p=<0.001). Both low- and high-volume HIIT significantly increased flow-mediated dilation (↑58.8% and ↑94.1%, p<0.001) and decreased carotid intima-media thickness and oxidized LDL in post-AMI patients.