A TAPSE/sPAP ratio <0.18 mm/mmHg predicts mortality in pulmonary arterial hypertension and improves risk stratification when combined with established risk scores (P<0.001).
Observational (n=156)
p-value: p=<0.001
Background: The tricuspid annular plane systolic excursion and systolic pulmonary artery pressure (TAPSE/sPAP) ratio has been proposed as an indicator of ventriculo-arterial coupling, predicting right ventricular failure (RVF) and mortality in patients with pulmonary arterial hypertension (PAH). Objective: To evaluate the usefulness of the TAPSE/sPAP ratio in predicting outcomes and improving risk stratification in patients with PAH. Methods: 156 patients with PAH were included. Clinical, functional, echocardiographic, and haemodynamic variables, along with the TAPSE/sPAP ratio, were analysed based on etiological PAH subgroups and outcomes. Additional statistical measures, such as the area under the curve (AUC), net reclassification index (NRI), and integrated discrimination improvement, assessed the predictive ability of TAPSE/sPAP in combination with the ESC/ERS risk score, and other risk assessment strategies (COMPERA and Reveal Lite 2). Results: < 0.001). Conclusions: A TAPSE/sPAP ratio <0.18 mm/mmHg predicts mortality in PAH. The combination of the TAPSE/sPAP ratio with the ESC/ERS risk score improved risk stratification, and reclassification emphasizing the potential of ESC/ERS+TAPSE/sPAP as a valuable tool for risk assessment and clinical decision-making in PAH patients. Integration of TAPSE/sPAP ratio with other scores (COMPERA and (REVEAL Lite 2) also improved the risk stratification and reclassification of these risk scores.
Palacios-Moguel et al. (Sat,) conducted a observational in Pulmonary Arterial Hypertension (n=156). TAPSE/sPAP ratio was evaluated on Mortality (p=<0.001). A TAPSE/sPAP ratio <0.18 mm/mmHg predicts mortality in pulmonary arterial hypertension and improves risk stratification when combined with established risk scores (P<0.001).