Low-dose aspirin use significantly reduced the incidence of pre-eclampsia (13.2% vs 22.4%, HR 0.695) in high-risk pregnant women compared to no aspirin, without increasing the risk of postpartum hemorrhage.
Cohort (n=344)
No
Does low-dose aspirin prevent pre-eclampsia in high-risk pregnant women?
Low-dose aspirin effectively reduces the incidence of pre-eclampsia and related complications in high-risk pregnancies without increasing the risk of postpartum hemorrhage.
Hazard Ratio: 0.695 (95% CI 0.422–0.913)
Absolute Event Rate: 13.2% vs 22.4%
p-value: p=<0.001
Background Pre-eclampsia, characterized by hypertension and organ dysfunction during pregnancy, poses significant risks to both maternal and fetal health. Aspirin, known for its antiplatelet properties, has been extensively utilized to mitigate pregnancy-related complications. However, the efficacy of low-dose aspirin in managing pre-eclampsia among high-risk pregnant women and its potential impact on postpartum hemorrhage remain contentious topics. Methods A retrospective analysis was conducted on 344 pregnant women diagnosed with high-risk factors for pre-eclampsia. Among them, 152 received intervention with low-dose aspirin, while the rest did not receive it. The incidence of pre-eclampsia, as well as related complications and outcomes associated with bleeding, were compared and evaluated between the two groups. Results The study findings indicate a significant reduction in the incidence of pre-eclampsia among pregnant women receiving low-dose aspirin intervention, along with a significantly reduced risk of complications. Additionally, there was no significant statistical difference in postpartum hemorrhage between the two groups ( p 0.05). The safety profile of aspirin usage was found to be favorable. Conclusion Low-dose aspirin demonstrates promising efficacy as an intervention strategy for high-risk preeclamptic women. It does not increase the risk of postpartum hemorrhage and reduces the occurrence of complications associated with preeclampsia. Therefore, low-dose aspirin presents a potential preventive measure against adverse outcomes associated with high-risk pregnancies related to preeclampsia. Further research is necessary to validate and elucidate the optimal dosage and timing of administration for maximal benefits.
Zhang et al. (Fri,) conducted a cohort in Pre-eclampsia (n=344). Low-dose aspirin vs. No aspirin was evaluated on Incidence of pre-eclampsia (HR 0.695, 95% CI 0.422-0.913, p=<0.001). Low-dose aspirin use significantly reduced the incidence of pre-eclampsia (13.2% vs 22.4%, HR 0.695) in high-risk pregnant women compared to no aspirin, without increasing the risk of postpartum hemorrhage.