Estrogen treatment significantly improved baroreflex sensitivity and reduced the expression of inflammatory cytokines and oxidative stress in ovariectomized female Wistar rats.
Does 17-beta estradiol valerate improve baroreflex sensitivity, hemodynamics, and inflammatory markers in ovariectomized female Wistar rats?
In an ovariectomized rat model, estrogen replacement improved baroreflex sensitivity and reduced oxidative stress and inflammation, providing mechanistic insight into its cardioprotective effects.
p-value: p=<0.05
Objective: This study aims to explore the role of estrogen in providing cardioprotective benefits to premenopausal women, examining how hormonal differences between sexes influence the prevalence of cardiovascular diseases (CVDs) in women. Materials and methods: 2 µg/mL/kg after ovariectomy. Hemodynamic parameters and baroreflex sensitivity were determined in all groups. Plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) were measured, along with those of the inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high mobility group box-1 (HMGB-1). Results: group, estrogen treatment considerably improved baroreflex sensitivity and hemodynamic profile while reducing the expression of inflammatory cytokines compared with the OVX group, demonstrating anti-inflammatory actions of estrogen. Conclusion: Estrogen mediates cardioprotection by improving baroreflex sensitivity in ovariectomized Wistar rats through modulation of the NO pathway.
Alam et al. (Mon,) conducted a other in Estrogen deficiency (Ovariectomy) (n=18). 17-beta estradiol valerate vs. Oral saline solution (Ovariectomized control) was evaluated on Baroreflex sensitivity and inflammatory markers (p=<0.05). Estrogen treatment significantly improved baroreflex sensitivity and reduced the expression of inflammatory cytokines and oxidative stress in ovariectomized female Wistar rats.