Intravenous antihypertensive treatment for severe inpatient hypertension does not benefit most patients, with counterfactual models suggesting most will still develop acute kidney injury.
Observational
Does treatment with intravenous antihypertensives within 3 hours of severe blood pressure elevation affect the time to developing acute kidney injury in hospitalized patients?
Exploratory analysis suggests that treating severe inpatient hypertension with IV antihypertensives may lead to acute kidney injury in most patients without providing clear benefit.
RATIONALE however, this could lead to acute kidney injury (AKI). We wanted to assess whether this is consistent across all patients, using a new statistical approach that predicts what would happen if patients who were treated had not been treated and those who were not treated had been. We found that most patients will develop AKI, and only a small subset of patients might not. This exploratory study can help inform future studies on the treatment of hypertension that develops during hospitalization.
Ghazi et al. (Fri,) conducted a observational in Severe hypertension during hospitalization. Intravenous antihypertensives vs. No intravenous antihypertensive treatment was evaluated on Time to developing acute kidney injury (AKI). Intravenous antihypertensive treatment for severe inpatient hypertension does not benefit most patients, with counterfactual models suggesting most will still develop acute kidney injury.